Mikhail Blagosklonny; the Distinguished Medical Oncology Researcher

For a long time, scientists have held the notion that aging results from a functional decline that cannot be prevented. The decline in function is as a result of the accumulation of random molecular. The hyper function theory proposed by Mikhail postulates that aging is a harmful continuation of growth caused by increased signalling of the m TOR pathways which convert the reversible cell into geroconverson. Evolutionists who have studied the signalling of m TOR pathways said that the increased activity in early development is essential for human development, but the continued excess activity is harmful in old age as it causes aging which results in death. Dr. Mikhail studied Rapamycin and found out that, in proper doses and schedules it extends a healthy lifespan by improving immunity in old age. In2006, rapamycin was approved for the clinical use in treating cancer, CDV, metabolic disorders, autoimmune disorders, osteoporosis, and Alzheimer’s. The clinical data on the drug showed that it has anti-tumour effects making it very potent for cancer treatment and also has bone sparing effects, making it a good anti-aging drug. The studies also showed that it mimicked calorie restriction by increasing lipolysis, which prevents true type II diabetes.

In his theory, he proposed that aging could be decreased by administering Rapamycin, which decreases the signal of the mTOR pathway hence slowing down the aging process. In his studies, Rapamycin was shown to suppress geroconversions on m TOR pathway partially. View Mikhail’s profile in LinkedIn

In his study of human diseases, m TOR pathway was linked to all age-related diseases that cause death namely: Parkinson’s, Alzheimer’s, Cancer, Benign tumors, Cardiac Fibrosis, atherosclerosis, renal hypertrophy, and diabetic complications. The hyperfunction of mTOR in old age is what leads to hypertension, hyperinsulinemia, and organ hypertrophy all which directly cause death.

Dr. Mikhail argued that humans living in a protected environment, free from infections and exposure to harmful toxins, die from age related diseases. Mikhail Blagosklonny proposed that with the right dosing and scheduling of Rapamycin as well as calorie restriction, they can delay age-related diseases including cancer hence extending the maximum life span. Just like bypass surgery can allow diseased individuals with aging-associated atherosclerosis to continue living, so will medical research focused on post-aging syndrome increase longevity in 50 years. He emphasized on the need of medical researchers and scientists to lay emphasis in research on the signs of post-aging syndrome so that once they are recognized, scientific measures can be implemented to fight the aging symptoms once they begin appearing.

About Mikhail Blagosklonny

Mikhail Blagosklonny is interested in investigating the underlying aging mechanism, cancer, anti-aging drugs, and targeted cancer drugs that prevent cells from getting destroyed. He hypothesized the role of TOR in mammals in causing cancer and aging, and he proposed the use of Rapamycin a popular cancer drug in elongating life.

In the research world, he is the chief editor of Oncotarget and Cell Cycle. An associate editor of cancer biology and therapy, an associate editor of PLOS ONE, and an editorial board member of Cell Death and Differentiation.

Read more: http://www.aging-us.com/article/100591/text

His publications

He’s authored aging hyperfunction theory, writes on psychotherapy and, chemotherapeutic engineering. He has written 300 research articles, reviews, and book chapters

He is one of the most revered Oncology researchers in the world, and he hopes to see a disease free world because he believes cancer can be cured and life can be prolonged

Roberto Santiago has The Best Shopping Center in Brazil, Paraíba

In Brazil, many shopping malls exceed in being some of the best across Latin America, because there is a lot of work that is put into them, and Brazilians love doing their shopping in the biggest malls in their cities.

In São Paulo, for example, there is the Morumbi Shopping, which has received dozens of awards for its large size and the amount of unusual and interactive leisure activities that you can do with the family.

Now, it’s time to talk about the biggest shopping mall in the Brazilian state of Paraíba: The Manaíra Shopping, created by Roberto Santiago, one of the most prominent entrepreneurs in the Brazilian business of “shoppings.”

Although it is not the most famous or populated state in Brazil, Paraíba is a place where cultural diversity is very rich and prominent. The Manaíra Shopping was built to have the standards of an international shopping mall, with the size of the best buying centers in the world, and leisure activities that match the best of what the Brazilian community likes to do in a group. Read more on Mundo Do Marketing

On November, 11 of 1989, the shopping mall was inaugurated, and it was one of the best malls available in the entire country at that time, beating some of the most visited centers of the country, like the malls of São Paulo and Rio de Janeiro, or even the Federal District. The construction of the mall exceeded a maximum of two years, but those who visited the buying center at its inauguration would not recognize the same place now in 2017.

When we say that Roberto Santiago is a great businessman and that he understands the market, one of the best examples to showcase his ability to keep things fresh is the extensive list of changes and improvements that he has made to the shopping mall across the period of existence of the building.

In 2013, more notably, Roberto Santiago ordered a massive construction to be conducted to increase the size of the shopping and extend the building so it could have more spaces for parking slots and leisure activities. It was very well received by the local population, and it was also done in a very impressive timespan as well.

In 2014, another change was conducted, and it was designed for the visitors who have the best monetary conditions, as the entrepreneur inaugurated a gourmet space in the lunching area of the shopping, where many eccentric restaurants of the most varied cultures and countries of origin share a luxurious space and people can eat a variety of foods that they had never tasted before. Again, the reception was phenomenal, and the shopping mall became something that the businessman Roberto Santiago was not expecting: A must-see local entertainment for tourists. Read more articles on exame.abril.com

Approximately 20 million people visit the shopping center per year, and that is one of the most impressive numbers in the very populous country that Brazil is. The number has increased drastically in the last couple of years because of the significant changes that took place in the building, which increased the quality of the services provided by a large margin.

Why Fabletics is the It Company of the Athletic Wear Future

Kate Hudson’s line of ultra-chic athletic clothing, Fabletics, is sweeping the globe. The brand has grown from infancy just three years ago to a $250 million giant that is gaining market share in the athletic wear space daily and going up against brands that have been around for decades.

 

So what is the secret? First, the brand is extremely buttoned up. Kate Hudson knows what she’s doing, knows trends and makes sure her company is consistently evolving to “surprise and delight” its users each month with a great bundle of athletic wear delivered right to their doorstep. From trendy leggings to fun tops with cut outs and playful colors, each package is as exciting to open as it is to wear to the gym or yoga class.

 

Second, Fabletics utilizes a reverse showroom platform. Here, they don’t push users to visit actual stores and check out displays that are built for everyone, but they create a unique digital experience that is tailored to the individual users wants and needs. How to they tailor it? Well, the website journey starts with a fun Lifestyle Quiz by Fabletics. The quiz asks questions to learn about each user and after answering, the items shown to you are curated to meet your needs and personal style that you filled out in the quiz. If you haven’t already, take 5 minutes to fill it out on the website.

 

By creating this reverse showroom in the digital space, Fabletics doesn’t pay the big bucks to open a chain of stores where customers come to browse and then go home and buy those same pieces online. Customers know they are getting the best price from Fabletics because of the low overhead. This also means Fabletics can offer customers higher quality at more moderate prices – something that was truly missing from the athletic wear market before Fabletics came along.

 

For a great review of the product, you can check out the un-paid review from A Foodie Stays Fit, found here . This particular blogger stressed how great the quality of Fabletics’ products were, she especially focused on the leggings. She said that the leggings were of such great quality that they were snug enough to make her legs and backside look great, with high end material and that they held their shape extremely well. She also shared some great photos of her sporting the tops, which were very stylish and had cutouts in all the cool places as well as a variety of colors. Overall, she recommended Fabletics to anyone looking to get fit in style.

 

Learn About Richard Blair; the Founder of Wealth Solutions

Wealth Solutions, whose headquarters are based in Austin, is an investment advisory firm whose operations are under Registered Investment Advisory firm. The company offers services that allow the clients to grow, guard, and manage their resources. Richard Blair is the founder of Wealth Solutions, a resourceful advisor, and partner who relates well with the clients. Blair and his firm operate under the belief that everybody needs a solid plan if they are to achieve their goals. Thus, the aim of the business is to arm Austin, Texas, community by offering the both management service of wealth and retirement plans to the customers.Learn more : http://anthonycioe.com/richard-blair-providing-sound-investment-and-wealth-solutions-to-clients-in-austin-texas/

 

Richard Blair of Wealth Solutions works under an inclusive three pillar approach. Pillar one approach is designed to help clients create their financial roadmap. This is done by identifying the strengths, objectives, risk, and growth opportunities. Blair believes that by helping clients understand where they are coming from, then it will be easy to assist them to forgo a great financial roadmap that they should use. The pillar two approach is designed to develop a long- term strategy, which meets with the investment needs of the clients. The approach is custom made to fit specific needs and investment goals. Wealth Solutions reallocates and manages the property so that they can make sure that they give maximum performance to the client when the market is suitable as well as reducing the impact of the investment of customers during the negative market periods. The third pillar is meeting the insurance needs of the clients that are the long term care, annuities, and life insurance. The approach involves the firm discovering the financial situation of the clients, the retirement needs that they might have and plan to come up with a holistic plan that fits the situation of each client.

 

About Richard Blair

 

The idea by Richard Blair to give financial advice to small businesses and individuals came from the teachings of his family. Both his mother and grandmother were teachers, and from them, he learned how teaching not only increase knowledge but also boosts one’s confidence. Putting this in mind and the fact that Blair is fascinated with finance, he joined the investment world in 1993, immediately after college. A year later, he started Wealth Solution The firm offers unbiased advice to the clients without any conflict of interest. Blair keeps up with the latest trends to ensure that he gives the customers the best and ensure that they have successful living after they have retired.Learn More : https://www.wealthminder.com/financial-advisors/TX/bee-cave/richard-blair/326407

 

 

 

 

Interesting Facts about Richard Mishaan’s Design

Beauty lies in the eyes of the beholder. Richard Mishaan has made this old saying a fact. Through his striking designs, Richard has brought architecture, fashion and interior design to life. Mr. Mishaan is the previous employee of Philip Johnson, a man that took Richard under his wing right after college. It is while Mishaan was working for Mr. Philip that he was able to hone his skills in fashion, interior design, and architecture.

With Mishaan having been an active professional in architecture and interior design, he was disturbed by the fact that many people did not appreciate the existing models that were in the market as he was starting his career. To this end, he did a little bit of research on what most of the clients in his locality were looking for and was able to come up with his unique designs. It is these beautiful designs that have made Richard known to the world.

Based on skills and years of experience, Mishaan has authored two books that showcase Richard Mishaan design. Both the Modern Luxury and Artfully Modern editorials are written content that has made a mark in the architectural world. In his lifetime, Richard has done deals with companies, especially from the hotel industry. Richard Mishaan has also been actively participating in residential projects, with designs on the hotel industry being almost coherent with those he uses in homes. Richard develops his designs by integrating those styles he finds through research, travel, and even visiting art galleries across the globe. Over the years, glamour, comfort, and quality have become Richard’s guiding principles.

Richard Mishaan design is incredibly unique because Richard Mishaan blends in different colors while working on antique and modern styles. A visit to Richard’s home says volumes about Mishaan’s level of expertise. He derives his inspiration from a room full of antiques that he once visited. By maintaining high levels of discipline, Richard has been able to dominate the interior design sector. By staying faithful to the course, Richard has found out that culture and travel can yield beautiful designs. Therefore, Richard has proved to the world that we can still rely on old models since they are not only timeless but also pure.

The Intriguing Nick Vertucci’s Real Estate Academy

Nick Vertucci has a very inspiring success story. He was brought up by a middle-income family where they lacked not the basics. However, this was short-lived by the demise of his parental father, and the mother became the sole breadwinner. In his teenage years, he began hustling to supplement her mother’s income. Through hard work and much sacrifice, he began a computer parts shop which took off well. With technological shifts, he found himself at loggerheads again. For the next about two years, Vertucci was constrained in finances.

Amidst his state of hand to mouth income and demanding family needs, his friend persuaded him to attend a real estate workshop. He declined to the proposal but finally gave in after the friend convinced him it was worthwhile. As he sat, Nick Vertucci started getting some highlights although could not absolutely grasp everything. From then Nick Vertucci developed an interest in real estate but had little knowledge of the subject. Nevertheless, he knew crystal clear if he pursued the opportunity, it would bear fruits worth the hassle.

Information and research propelled him to fully indulge in real estate. Nick Vertucci established the Nick Vertucci Real Estate Academy to teach and share the resourceful information thereof. The institution uses the Fortunes in Flipping System in teaching buying of property, refurbishing them and benefiting from the sale. Thousands of NVREA students have benefited from the program. Reports indicate they are doing very well in the real estate world. Those taking the learned principles in action have invested mightily and are already ripping the fruits.

The growth of NVREA shows how welcome the idea is more so because it is a 100-percent free program on highya.com. To be effective, the program covers the areas of how to get started, tips on becoming an apex real estate guru, balancing and managing the business, inflation proofing, lock down income generating properties, capital sources and management and active strategies. From feedback, it is a prime opportunity to gather up knowledge and implement the same in real estate investment.

About Nick Vertucci Real Estate Academy
The program has engaged a lot of students since its foundation in 2013. The academy is run by a team of 9 corporate members in the executive, and 29 trained tutor and a support staff of 20 members. Besides, the education NVREA comes with the promise of asset protection, commercial investment, leveraging, flipping contracts among other goodies at https://www.linkedin.com/in/nick-vertucci-43aa7066.

Honey Birdette-Get That Spark Back into Your Love Life

Honey Birdette, an Australian lingerie brand has just launched its e-commerce site dedicated to its US customer base to keep up with the demand. The company experienced a 374% increase in just 12 months form its US market and the new site offers free shipping on orders over $50 as well as faster shipping and easier returns.

As seen on their Instagram, Honey Birdette has 55 stores in its native country of Australia and already has three stores in the UK located in London’s Covent Garden, Leeds’ Victoria Gate, and Westfield White City. The store in London’s Covent garden was the very first store that opened outside of Australia. Honey Birdette is expected to expand to a count of 40 stores in the UK including store locations at Leeds, Newcastle, Liverpool, and Westfield Stratford. Honey Birdette isn’t stopping there, though, and has its eye on the European market as well.

Honey Birdette did not come to be by accident but rather, the thought of the brand was thought of when two friends were chatting over champagne. It quickly became clear that there just wasn’t an enticing lingerie market and that had to change. And it did. Honey Birdette was born in 2006 and has quickly grown to become very successful and sought-after.

Honey Birdette is all about reigniting that spark in your love life and making the bedroom exciting again. The brand is also all about embracing your intense sexuality and wearing it with pride. There are many different toys and collections to choose from in their boutiques and online stores and there is something everyone, every occasion, and every fantasy from bras to massage candles. They most definitely have it all. You can even sip some champagne as you browse their collection in-store and decide on which new fetish you may get into next.

Find more Honey Birdette on YouTube.